Beyond the Count: Measuring Sperm DNA Quality for Reproductive Success
At Sparsh IVF, we believe that successful conception is not just about how many sperm are present — but how healthy and genetically stable they are. While a standard semen analysis checks sperm count, motility, and morphology, it cannot detect internal DNA damage. That’s where the Sperm DNA Fragmentation Index (DFI) test comes in.
This advanced diagnostic tool helps us assess the genetic integrity of sperm, offering valuable insight for couples facing unexplained infertility, repeated IUI or IVF failures, and recurrent pregnancy loss.
Sperm DNA fragmentation refers to the presence of breaks or damage in the genetic material (DNA) within the sperm head. Even if sperm look normal and swim well, high DNA fragmentation can affect:
DFI testing measures the percentage of sperm with fragmented DNA in a semen sample. The higher the fragmentation, the lower the sperm’s ability to support a healthy pregnancy — especially in ICSI or IVF.
While traditional semen analysis is useful, it doesn’t reveal hidden defects in sperm genetics. That’s why DFI testing is often recommended for couples with:
At Sparsh IVF, we include DFI testing in our advanced male fertility evaluation, especially when prior treatments have failed or sperm morphology appears borderline.
The process is non-invasive, painless, and can be done in conjunction with routine semen testing.
| DFI Score | Interpretation |
|---|---|
| <15% | Excellent DNA integrity (low risk) |
| 15–25% | Moderate damage (may affect IVF/ICSI outcomes) |
| >25% | High DNA fragmentation (associated with infertility, miscarriage, failed ART) |
Your fertility doctor at Sparsh IVF will help interpret these results and correlate them with clinical history and treatment goals.
Common contributors include:
Identifying and managing these factors can help reduce DFI over time.
Yes — while DNA damage cannot always be reversed, several approaches can help improve sperm quality:
At Sparsh IVF, your fertility expert will offer personalized strategies based on your DFI score and reproductive goals.
DFI results influence key fertility decisions:
This helps improve IVF success rates, embryo quality, and ultimately, the chances of a healthy pregnancy.
If you’re facing unexplained infertility, failed IVF cycles, or repeated early pregnancy loss, a Sperm DNA Fragmentation Test at Sparsh IVF may be the missing piece in your diagnosis.
Schedule your DFI consultation and test today — and take a deeper look into the health of your future.
Sometimes, the problem isn’t what the sperm looks like — it’s what it carries. Let’s find out, together.
Book Appointment